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July 2017
AZ opens its preclinical safety data contribution to eTOX

AstraZeneca makes its preclinical safety data contribution to eTOX available to the broader scientific community through its Open Innovation portal.

 

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February 2017
eTOX Final Newsletter

eTOX Newsletter has been launched.

 

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eTOX news

 

 

AZ opens its preclinical safety data contribution to eTOX

 

20th July 2017

AstraZeneca makes its preclinical safety data contribution to eTOX available to the broader scientific community through its Open Innovation portal.

Dr Nigel Greene, Director of Predictive Compound ADME & Safety in AstraZeneca said:“Following on from the success of the eTOX project, we are keen to further broaden access to our preclinical safety data in order to help advance the mechanistic understanding and prediction of drug safety and bring safer medicines to patients faster."

Scientific researchers can submit brief project proposals outlining their intentions and the anticipated benefits from their work, after which the data will be shared at AstraZeneca’s discretion. Anyone interested in accessing AstraZeneca’s preclinical data sets for data mining and research purposes can submit their proposals via the following link: https://openinnovation.astrazeneca.com/data-library.html#preclinical.

This initiative represents an example of an increasingly popular trend, and shows how the eTOX project, funded by the European Commission and several pharmaceutical companies, has signified a paradigm change in the pharmaceutical industry’s willingness to openly share legacy data for the benefit of the wider toxicology community.

 

 

eTOX Newsletter - Issue Num 21 Final

 

28th February 2017

Issue Num. 21 Final of the eTOX Newsletter has been launched in February. A final keynote by the Executive Committee of eTOX and the handover to the eTOXsys Business Broker is included. Additionally, final facts and figures for the whole lifetime of the project are summarised.

To download Issue Num. 21 Final please click here. To download past Newsletters visit the Newsletter Archive.

 

 

eTOX Final Meeting

 

5th December 2016

On the 28th and 29th of November 2016, we celebrated the successful completion of the eTOX project with a conference on Project achievements and future perspectives.

Over 70 attendees representing all eTOX partners as well as external invitees, all covering a broad cross-section of backgrounds, gathered to discuss the lessons learned from the success of eTOX and initiate the steps towards a promising sustainability phase.

Looking back there have been some challenges along the 7 years of the project. But overall the development of the system and the future plans for sustainability are quite promising, as well as other important achievements of the project. All of them demonstrating the need to jointly work private and public sectors together.

IMI Officer, Hugh Laverty, congratulated all eTOX partners and its management team; there has been an outstanding learning curve, as stemming from Call 1 in IMI1. The challenge of getting of getting the data was initially underestimated but an important DB with over 7000 reports from all EFPIA companies participating in the project has been achieved. The Honest Broker model created in eTOX has been repeated in other projects.

The final version of the system, eTOXsys v3 will be launched in the coming weeks. The eTOXsys TM will continue the work during the upcoming sustainability phase. A demo of the system will also be launched soon.

 

 

eTOX Newsletter - Issue Num 20

 

30th September 2016

Issue Num 20 of the eTOX Newsletter has been launched in June.

If you wish to receive the quarterly eTOX Newsletter, subscribe at editorial@e-tox.net.

To download Issue Num 20 please click here. To download past Newsletters visit the Newsletter Archive.

 

 

eTOX Newsletter - Issue Num 19

 

30th June 2016

Issue Num 19 of the eTOX Newsletter has been launched in June.

If you wish to receive the quarterly eTOX Newsletter, subscribe at editorial@e-tox.net.

To download Issue Num 19 please click here. To download past Newsletters visit the Newsletter Archive.

 

 

eTOX Video

 

25th May 2016

eTOX launches a video presenting the 2nd Hackathon event held at the PRBB, which also gives an insight into the project.

The second edition of the eTOX Hackathon was held in Barcelona on 7-10 March 2016 at the Barcelona Biomedical Research Park (PRBB). The hackathons are focused in toxicology modelling and participants cover a wide spectrum of backgrounds: from industry toxicologists companies like Novartis, Bayer, Sanofi, and Roche to academic bioinformaticians such as FIMIM, Fraunhofer, CNIO and UPV, and SMEs Lead Molecular Design, Lhasa Ltd and Molecular Networks. Intense and efficient inter-disciplinary collaboration is challenging and, at the same time, a prerequisite for the eTOX objective of improved safety assessment. The three challenges undertaken this year have been:

1. Hepatotoxicity modelling

2. Incorporating additional data beyond the eTOX database

3. Multiscale drug-induced liver toxicity prediction tool

The hackathons produced in a few days original and valuable results. This success demonstrates the importance of an appropriate approach, and the enriching effect of inter-disciplinary collaboration in an adequate scenario to push the boundaries in the knowledge of toxicology.

Click here to whatch the video

 

 

 

 

 

 

 

 

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